Performances of the show, based on Dodie Smith’s classic book, were due to take place at 2pm and 7pm at Glasgow’s King’s Theatre.
It has not been disclosed if Friday’s performances will go ahead, or if its run on Saturday will happen.
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They wrote: “Customer announcement. We are sorry to say that due to cast illness, today’s 2pm and 7pm performances of 101 Dalmatians have been cancelled.
“All customers have been sent an email and text regarding details. If you have any further questions, please contact us via the Help Centre.”
The musical is scheduled for the King’s Theatre from November 12 to 16.